Many drugs fall in the Biopharmaceutics Classification System category of class II and class IV drugs i.e. low solubility/high permeability and low solubility/low permeability respectively. Due to their hydrophobicity, there is difficulty in forming a stable formulation. Crystal engineering is implemented with a water-soluble molecule (called conformer) and an active pharmaceutical ingredient to improve the aqueous solubility. This review primarily is written to provide a general understanding of the experimental techniques used during the screening of cocrystals. It also discusses the challenges and future perspectives of cocrystal engineering and their importance to be thermodynamically stable to be acknowledged as a potentially marketable product.
Cocrystallization, Cocrystals, Conformers, Crystal Engineering, Selection, Pharmaceutical Cocrystals, Screening, Solubility Enhancement.